Dr Rajesh Shah’s career is based on the strong conviction that homeopathy is a lesser understood medical science which can better be understood only by scientific research using the principles of physics, chemistry, biology, and mathematics.
A full-time clinician but a researcher by temperament, Dr. Shah has been devoting a lot of his time, energy, and resources to the development of research supported homeopathic treatment for his patients across the globe.
Some of the areas of work where Dr Shah has involved himself over the last decade are as under:
Research projects by Dr Rajesh Shah
i. Preparation of HIV nosode (May-2010)
A new HIV nosode sourced from HIV positive (type I and II negative for other co-infections) was scientifically prepared. The ethics committee, which is constituted and functions as per ICMR guidelines approved a project. The source material, fifteen-step preparation process, and the standardization with respect to viral count, protein profile, pH, and the process of potentization were documented. The HIV nosode in 30c and 50c potencies was prepared. Safety and efficacy were established through clinical trials and homeopathic pathogenetic trials (Drug proving).
ii. Homeopathic Pathogenetic Trial of HIV nosode (June-2011)
A double-blind, randomized placebo-controlled homeopathic pathogenetic trial (drug proving) of HIV nosode, 30c potency was conducted using accepted guidelines, ethical approval, and scientific documentation; with the aim to introduce a new nosode in the homeopathic pharmacopeia. Usable symptoms derived from the study.
iii. HIV nosode clinical trial (May-2010)
An open-label exploratory clinical trial in thirty HIV-positive individuals was conducted using the HIV nosode in 30c and 50c potencies. The objectives of this study were to evaluate the efficacy of HIV nosode in HIV-infected participants in terms of reduction in viral load and improvement of immunological parameters such as CD4 and CD8 count and CD4 percentage and general health parameters.
iv. Preparation of HCV nosode (May-2010)
HCV nosode from sera of HCV type I and III positive (negative for other co-infections) consented donors were prepared by serial dilution and potentization method described in Homeopathic Pharmacopeia. The source material and the preparation process were standardized. The HCV nosode in 30c and 50c potencies was prepared. Safety and efficacy were established through clinical trials and homeopathic pathogenetic trials (Drug proving).
v. HCV nosode clinical trial (May-2010)
An open-label exploratory clinical trial in twenty-six HCV-positive individuals was conducted using the HCV nosode in 30c and 50c potencies. The main objective of this study was to evaluate the efficacy of HCV nosode by observing the reduction in viral load from baseline and general health parameters.
vi. Homeopathic Pathogenetic Trial of HCV nosode (June-2011)
A double-blind, randomized placebo-controlled homeopathic pathogenetic trial (drug proving) of HCV nosode, 30c potency was conducted using accepted guidelines, ethical approval, and scientific documentation; with the aim to introduce a new nosode in the homeopathic pharmacopeia. Usable symptoms derived from the study.
vii. Homeopathic Pathogenetic Trial of CP-010 (Jan- 2012)
A double-blind, randomized, placebo-controlled homeopathic pathogenetic trial (HPT/ drug proving) of CP-010 was conducted, using the accepted guidelines, ethical approval, and scientific documentation.
viii. CP-010 clinical trial for pain management (Nov-2011)
A double-blind, randomized, comparative study to evaluate efficacy and safety of CP- 010 with Magnesium phosphoricum was conducted. 116 patients having sub-acute and chronic painful conditions were randomized in the study.
The primary objective of this study was to evaluate the efficacy of potentized preparation CP-30c potency by measuring the reduction in the intensity of pain using Numeric rating scale (NRS).
ix. Homeopathic Pathogenetic Trial of H-009 (Jan- 2012)
A double-blind, randomized, placebo-controlled homeopathic pathogenetic trial (HPT/ drug proving) of Hydroquinone was conducted, using the accepted guidelines, ethical approval, and scientific documentation; with the aim of introducing a new medicine in the homeopathic pharmacopeia.
x. Preclinical study (animal- Wistar rats) to evaluate the efficacy of CP 010 in arthritis (Oct- 2012)
The anti-arthritic activity of CP 010, magnesium phosphoricum was studied in 60 Albino Wistar rats in 6 different groups using the positive and negative control to observe the effect of homeopathy medicines on an animal model. The study proved that homeopathic medicines are as effective as anti-inflammatory Diclofenac on certain days.
xi. Preparation, Standardization and in vitro safety testing of Mycobacterium Nosodes (Emtact- Polyvalent Nosode)(Jan- 2013)
Polyvalent Mycobacterium nosode (Emtact) was prepared and standardized using different Mycobacterium strains. Bacterial characteristics, strains, and quantity used, and the process of preparation was documented so that the nosodes can be re-visited, re-developed with scientific validation and standardization. In vivo studies and sterility testing of the nosode.
xii.
A method for preparation of Nosode developed: Old method of nosode preparation required revamping in the light of the latest development in the areas of microbiology. A scientific, standardized 15 step method was developed for making reproducible nosodes now and in the future.
xiii.
Animal study to see the immune-modulator effect of nosodes. (Ongoing).
xiv.
Many others
Publications: Articles
Some of the research conducted by Dr Shah has been published in peer-reviewed, international journals:
01“Clinical trial for evaluation of a Human Immunodeficiency Virus nosode in the treatment of Human Immunodeficiency Virus-Infected individuals”; Indian Journal of Research in Homoeopathy / Vol. 9 / Issue 1 / Jan-Mar 2015. Link: http://www.ijrh.org/article.asp?issn=0974-7168;year=2015;volume=9;issue=1;spage=25;epage=33;aulast=Shah
02 “HIV Nosode: The Homeopathic Pathogenetic Trial,” by Rajesh Shah, MD, published in ForschendeKomplementärmedizin / Research in Complementary Medicine, Germany, June 2015. Link: https://www.karger.com/Article/Abstract/435845
03 “Clinical trial for evaluation of a Human Immunodeficiency Virus nosode in the treatment for Human Immunodeficiency Virus-Infected individuals”, Indian Journal of Research in Homoeopathy [serial online] 2015 [cited 2015 April];8:166-74. Available from: http://www.ijrh.org/article.asp?issn=0974-7168;year=2015;volume=9;issue=1;spage=25;epage=33;aulast=Shah;type=0
04 “Scientific method of preparing homeopathic nosodes. “ Indian Journal of Research in Homoeopathy [serial online] 2014 [cited 2014 Nov 13];9: 25-33. Available from: http://www.ijrh.org/text.asp?2014/8/3/166/141740
05 "Effect of Orally Administered Potentized Capsaicin and Dihydrocapsaicin in Humans: A Homeopathic Pathogenetic Trial", by Rajesh Shah, MD, published in ForschendeKomplementärmedizin / Research in Complementary Medicine, Germany, June 2014. Link: https://www.karger.com/Journal/Issue/261932
06 "Potentized, an oral preparation of capsaicin alkaloids and magnesium phosphoricum in the treatment of chronic pain: A clinical trial" by Rajesh Shah, MD, published in American journal "JOURNAL OF PAIN MANAGEMENT", Nova Publishers, NY, USA,
Volume 7, Number 1, 2014
Link: https://www.novapublishers.com/catalog/product_info.php?products_id=48676
07“Hepatitis C Nosode: The preparation and homeopathic pathogenetic trial” in Homeopathy; Vol. 102, (3), pp 207-214: July 2013. Link: http://www.ncbi.nlm.nih.gov/pubmed/23870381
08 “Hydroquinone: Homoeopathy pathogenetic trial” in Indian Journal of Research in Homoeopathy; Vol. 7 (2): Apr-Jun 2013. Link: http://www.ijrh.org/article.asp?issn=0974-7168;year=2013;volume=7;issue=2;spage=47;epage=61;aulast=Shah
09 “Challenge in the management of cases earlier treated with immuno-suppressive medicines”
(Desafioscolocadosaotratamentohomeopáticopelouso anterior de medicaçãoimunossupressora: Observações da práticaclínica), Revista de Homeopatia, Brazil, Vol. 74, No 4 (2011)https://www.aph.org.br/revista/index.php/aph/article/view/220