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Nephrotic Syndrome: Adverse effects of Cyclosporine

Cyclosporine is a immunosuppressant drug widely used in post-allogeneic organ transplant such as kidney, liver or heart to reduce the activity of the patient's immune system.

Cyclosporine is a conventionally used medicine for autoimmune diseases such as Psoriasis, Rheumatoid arthritis, Crohn's disease, Nephrotic Syndrome, etc.where the patient does not respond to the treatment with corticosteroids or methotrexate.

Cyclosporine is a very good immune-suppressive medicine but makes the patient susceptible to infection including cancer such as lymphoma.

The adverse effects could be listed as:

1) Adverse effects, which require immediate medical help (alarming signs), are:

  • Hypertension: Above 50% of patients taking cyclosporine develops high blood pressure. Known case of hypertension has a risk of developing heart disease.
  • Kidney Dysfunction:Scanty urine presenting as decreased frequency of urination or no urine at all.
  • The risk of both these problems increases with higher doses and longer treatment with cyclosporine.
  • Allergic reactions presenting as hives, swelling of face lips and throat or difficulty in breathing.
  • Seizure (convulsion)
  • Tachycardia (fast heart rate), muscle weakness or pain
  • Flu like symptoms as fever chills and sore throat
  • Jaundice presenting as yellowing of skin and sclera, dark urine, nausea, clay colored stools.
  • Drowsiness, confusion and mood changes
  • Easy bruising and bleeding
  • Swelling and weight gain
  • gum disease or overgrowth

2) Less serious side effects include:

  • Abnormal Hair Growth: Both men and women may develop hair growth in abnormal amounts on the face, chest and arms.
  • Nausea and diarrhea
  • Tremor: Above 50 % people develop tremors characterized by shaking. Leg cramps or muscle contractions might also be experienced.

Special precautions before starting cyclosporine:

  • A person suffering from any kidney disease, uncontrolled hypertension or cancer are not eligible to take this drug.
  • Psoriasis patients who have had certain previous treatments like PUVA, UVB, coal tar, radiation therapy, methotrexate,etc are at higher risk to develop skin cancer.
  • Any "live" vaccine taken while you are being treated with cyclosporine will not be effective.
  • There are many other medicines like vitamins, minerals, etc. which can cause serious medical problems if you take them together with cyclosporine.
  • Do not start using any new medication without informing your doctor. Safest way is to keep a list of all the medicines you use and show this list to the doctor.
  • Avoid eating grapefruit or drinking grapefruit juice.

Adverse effects of CyclophosphamideAdverse effects of CyclosporineAdverse effects of Methotrexate

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Nephrotic Syndrome Case Studies

A 6-year-old child, Mast. A.Y. (PIN: 32603) visited Life Force Homeopathy clinic on 29th July 2017 for his complaint of Nephrotic syndrome, which he was suffering since April 2016. He was on conventional treatment along with steroids for alternate days for 4 months.
The parents of the pati.....Read more

An 11 years old boy Master. V. D. M. (PIN 37039 ) visited LIFE FORCE HOMEOPATHY on 2nd June 2018. He was suffering from Nephrotic syndrome since 2012. He had a brief remission for 4 months in 2017 and had a relapse. Now he had Urine Proteins in traces for almost 6 months. During this relapse.....Read more

A 4-year-old girl, A.P.S. (PIN: 36611) visited our Life Force clinic for the treatment of her complaint of Nephrotic syndrome on 26th April 2018. She was diagnosed with nephrotic syndrome in September 2017, and she was on conventional treatment along with steroids.

The parents of t.....Read more

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